Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer.

Dosch AR, Dai X, Reyzer ML, Mehra S, Srinivasan S, Willobee BA, Kwon D, Kashikar N, Caprioli R, Merchant NB, Nagathihalli NS
Mol Cancer Res. 2020 18 (4): 623-631

PMID: 31949002 · PMCID: PMC7127944 · DOI:10.1158/1541-7786.MCR-19-0741

MeSH Terms (20)

Animals Antineoplastic Combined Chemotherapy Protocols Carcinoma, Pancreatic Ductal Dasatinib Deoxycytidine Disease Models, Animal ErbB Receptors Erlotinib Hydrochloride Female Humans Mice Mice, Nude Pancreatic Neoplasms Protein Kinase Inhibitors Signal Transduction src-Family Kinases STAT3 Transcription Factor Stromal Cells Survival Analysis Xenograft Model Antitumor Assays

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