Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable.

Dai C, Walker JT, Shostak A, Padgett A, Spears E, Wisniewski S, Poffenberger G, Aramandla R, Dean ED, Prasad N, Levy SE, Greiner DL, Shultz LD, Bottino R, Powers AC
JCI Insight. 2020 5 (1)

PMID: 31941840 · PMCID: PMC7030815 · DOI:10.1172/jci.insight.130770

MeSH Terms (16)

Animals Calcineurin Diabetes Mellitus Graft Rejection Humans Immunosuppressive Agents Insulin Insulin-Secreting Cells Islets of Langerhans Islets of Langerhans Transplantation Male Mice Signal Transduction Sirolimus Tacrolimus TOR Serine-Threonine Kinases

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