Sirtuin 6 and renal injury: another link in the β-catenin chain?

Gewin LS
Kidney Int. 2020 97 (1): 24-27

PMID: 31901350 · DOI:10.1016/j.kint.2019.09.022

A protective role for sirtuin 6 (Sirt6) in the context of chronic renal injury is reported by Cai et al. in this issue of Kidney International. The mechanism is thought to be mediated by Sirt6's deacetylase activity, specifically on β-catenin target genes. This commentary discusses these results and the interaction between Sirt6 and β-catenin within the broader context of β-catenin signaling and injury.

Copyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

MeSH Terms (6)

beta Catenin Fibrosis Humans Kidney Kidney Diseases Sirtuins

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