Minimally invasive surgery to treat embryonal tumors of childhood.

Phelps HM, Lovvorn HN
Cancer Metastasis Rev. 2019 38 (4): 695-708

PMID: 31807970 · DOI:10.1007/s10555-019-09830-4

Minimally invasive surgery (MIS) to resect primary and metastatic pediatric embryonal tumors offers the potential for reduced postoperative morbidity with smaller wounds, less pain, fewer surgical site infections, decreased blood loss, shorter hospital stays, and less disruption to treatment regimens. However, significant controversy surrounds the question of whether a high-fidelity oncologic resection of childhood embryonal tumors with gross total resection, negative margins, and appropriate lymph node sampling can be achieved through MIS. This review outlines the diverse applications of MIS to treat definitively pediatric embryonal malignancies, including this approach to metastatic deposits. It outlines specific patient populations and presentations that may be particularly amenable to the minimally invasive approach. This work further summarizes the current evidence supporting the efficacy of MIS to accomplish a definitive, oncologic resection without compromising relapse-free or overall survival. Finally, the review offers technical considerations to consider in order to achieve a safe and complete resection.

MeSH Terms (10)

Child Child, Preschool Female Humans Infant Male Minimally Invasive Surgical Procedures Neoadjuvant Therapy Neoplasms, Germ Cell and Embryonal Neuroblastoma

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