Discovery of structurally distinct tricyclic M positive allosteric modulator (PAM) chemotypes.

Temple KJ, Long MF, Engers JL, Watson KJ, Chang S, Luscombe VB, Rodriguez AL, Niswender CM, Bridges TM, Conn PJ, Engers DW, Lindsley CW
Bioorg Med Chem Lett. 2020 30 (4): 126811

PMID: 31787491 · DOI:10.1016/j.bmcl.2019.126811

MeSH Terms (12)

Allosteric Regulation Animals Drug Design Half-Life Humans Inhibitory Concentration 50 Pyridazines Quinazolines Rats Receptor, Muscarinic M4 Structure-Activity Relationship Triazoles

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