Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M positive allosteric modulator (PAM) chemotype.

Temple KJ, Engers JL, Long MF, Watson KJ, Chang S, Luscombe VB, Jenkins MT, Rodriguez AL, Niswender CM, Bridges TM, Conn PJ, Engers DW, Lindsley CW
Bioorg Med Chem Lett. 2020 30 (3): 126812

PMID: 31784320 · DOI:10.1016/j.bmcl.2019.126812

MeSH Terms (10)

Allosteric Regulation Drug Design Drug Evaluation, Preclinical Humans Imidazoles Kinetics Protein Binding Pyrazines Receptor, Muscarinic M4 Structure-Activity Relationship

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