GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions.

Gerhard DM, Pothula S, Liu RJ, Wu M, Li XY, Girgenti MJ, Taylor SR, Duman CH, Delpire E, Picciotto M, Wohleb ES, Duman RS
J Clin Invest. 2020 130 (3): 1336-1349

PMID: 31743111 · PMCID: PMC7269589 · DOI:10.1172/JCI130808

MeSH Terms (15)

Animals Antidepressive Agents Female GABAergic Neurons Gene Knockout Techniques Glutamate Decarboxylase Interneurons Ketamine Male Mice Mice, Transgenic Parvalbumins Receptors, N-Methyl-D-Aspartate Sex Characteristics Somatostatin

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