Dynamic remodeling of a basolateral-to-central amygdala glutamatergic circuit across fear states.

Hartley ND, Gaulden AD, Báldi R, Winters ND, Salimando GJ, Rosas-Vidal LE, Jameson A, Winder DG, Patel S
Nat Neurosci. 2019 22 (12): 2000-2012

PMID: 31712775 · PMCID: PMC6884697 · DOI:10.1038/s41593-019-0528-7

Acquisition and extinction of learned fear responses utilize conserved but flexible neural circuits. Here we show that acquisition of conditioned freezing behavior is associated with dynamic remodeling of relative excitatory drive from the basolateral amygdala (BLA) away from corticotropin releasing factor-expressing (CRF) centrolateral amygdala neurons, and toward non-CRF (CRF) and somatostatin-expressing (SOM) neurons, while fear extinction training remodels this circuit back toward favoring CRF neurons. Importantly, BLA activity is required for this experience-dependent remodeling, while directed inhibition of the BLA-centrolateral amygdala circuit impairs both fear memory acquisition and extinction memory retrieval. Additionally, ectopic excitation of CRF neurons impairs fear memory acquisition and facilities extinction, whereas CRF neuron inhibition impairs extinction memory retrieval, supporting the notion that CRF neurons serve to inhibit learned freezing behavior. These data suggest that afferent-specific dynamic remodeling of relative excitatory drive to functionally distinct subcortical neuronal output populations represents an important mechanism underlying experience-dependent modification of behavioral selection.

MeSH Terms (13)

Animals Basolateral Nuclear Complex Central Amygdaloid Nucleus Conditioning, Classical Corticotropin-Releasing Hormone Excitatory Postsynaptic Potentials Extinction, Psychological Fear Freezing Reaction, Cataleptic Glutamic Acid Mice, Transgenic Neural Pathways Somatostatin

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