Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors.

Friggeri L, Hargrove TY, Wawrzak Z, Guengerich FP, Lepesheva GI
J Med Chem. 2019 62 (22): 10391-10401

PMID: 31663733 · PMCID: PMC6881533 · DOI:10.1021/acs.jmedchem.9b01485

MeSH Terms (10)

14-alpha Demethylase Inhibitors Animals Catalytic Domain Crystallography, X-Ray Drug Design Humans Molecular Structure Mutagenesis, Site-Directed Protozoan Proteins Sterol 14-Demethylase

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