Depressive Symptoms Predict Change in Telomere Length and Mitochondrial DNA Copy Number Across Adolescence.

Humphreys KL, Sisk LM, Manczak EM, Lin J, Gotlib IH
J Am Acad Child Adolesc Psychiatry. 2020 59 (12): 1364-1370.e2

PMID: 31628984 · PMCID: PMC7160006 · DOI:10.1016/j.jaac.2019.09.031

OBJECTIVE - Several studies have found associations between a diagnosis or symptoms of major depressive disorder and markers of cellular aging and dysfunction. These investigations, however, are predominantly cross-sectional and focus on adults. In the present study, we used a prospective longitudinal design to test the cross-sectional association between depressive symptoms in adolescents and telomere length (TL) as well as mitochondrial DNA copy number (mtDNA-cn).

METHOD - A total of 121 adolescents (mean age = 11.38 years, SD = 1.03; 39% male adolescents and 61% female adolescents) were followed for approximately 2 years. At baseline and follow-up, participants provided saliva for DNA extraction, from which measures of TL and mtDNA-cn were obtained. Depressive symptoms were obtained via the Children's Depression Inventory.

RESULTS - There was no association between depressive symptoms and markers of cellular aging at baseline; however, depressive symptoms at baseline predicted higher rates of telomere erosion (β = -0.201, p = .016) and greater increases in mtDNA-cn (β = 0.190, p = .012) over the follow-up period. Markers of cellular aging at baseline did not predict subsequent changes in depressive symptoms. Furthermore, including the number of stressful life events did not alter these patterns of findings.

CONCLUSION - These results indicate that depressive symptoms precede changes in cellular aging and dysfunction, rather than the reverse.

Copyright © 2019 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.

MeSH Terms (13)

Adolescent Adult Child Cross-Sectional Studies Depression Depressive Disorder, Major DNA, Mitochondrial DNA Copy Number Variations Female Humans Male Prospective Studies Telomere

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