Aspects of Prostaglandin Glycerol Ester Biology.

Kingsley PJ, Rouzer CA, Morgan AJ, Patel S, Marnett LJ
Adv Exp Med Biol. 2019 1161: 77-88

PMID: 31562623 · DOI:10.1007/978-3-030-21735-8_8

The Cyclooxygenase enzymes (COX-1 and COX-2) incorporate 2 molecules of O into arachidonic acid (AA), resulting in an array of bioactive prostaglandins. However, much work has been done showing that COX-2 will perform this reaction on several different AA-containing molecules, most importantly, the endocannabinoid 2-arachidonoylglycerol (2-AG). The products of 2-AG oxygenation, prostaglandin glycerol esters (PG-Gs), are analogous to canonical prostaglandins. This chapter reviews the literature detailing the production, metabolism, and bioactivity of these compounds, as well as their detection in intact animals.

MeSH Terms (7)

Animals Arachidonic Acids Cyclooxygenase 2 Endocannabinoids Glycerides Glyceryl Ethers Prostaglandins

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