Discovery of a novel 3,4-dimethylcinnoline carboxamide M positive allosteric modulator (PAM) chemotype via scaffold hopping.

Temple KJ, Engers JL, Long MF, Gregro AR, Watson KJ, Chang S, Jenkins MT, Luscombe VB, Rodriguez AL, Niswender CM, Bridges TM, Conn PJ, Engers DW, Lindsley CW
Bioorg Med Chem Lett. 2019 29 (21): 126678

PMID: 31537424 · DOI:10.1016/j.bmcl.2019.126678

MeSH Terms (11)

Allosteric Regulation Amides Azetidines Benzene Molecular Structure Protein Binding Pyrazines Pyridines Pyrimidines Receptor, Muscarinic M4 Structure-Activity Relationship

Connections (1)

This publication is referenced by other Labnodes entities:

Links