, a bio/informatics shared resource is still "open for business" - Visit the CDS website


Heterogeneity of Neural Stem Cells in the Ventricular-Subventricular Zone.

Rushing GV, Bollig MK, Ihrie RA
Adv Exp Med Biol. 2019 1169: 1-30

PMID: 31487016 · DOI:10.1007/978-3-030-24108-7_1

In this chapter, heterogeneity is explored in the context of the ventricular-subventricular zone, the largest stem cell niche in the mammalian brain. This niche generates up to 10,000 new neurons daily in adult mice and extends over a large spatial area with dorso-ventral and medio-lateral subdivisions. The stem cells of the ventricular-subventricular zone can be subdivided by their anatomical position and transcriptional profile, and the stem cell lineage can also be further subdivided into stages of pre- and post-natal quiescence and activation. Beyond the stem cells proper, additional differences exist in their interactions with other cellular constituents of the niche, including neurons, vasculature, and cerebrospinal fluid. These variations in stem cell potential and local interactions are discussed, as well as unanswered questions within this system.

MeSH Terms (8)

Animals Brain Cell Lineage Lateral Ventricles Mice Neural Stem Cells Neurons Stem Cell Niche

Connections (1)

This publication is referenced by other Labnodes entities:

Links