MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21.

Vilgelm AE, Saleh N, Shattuck-Brandt R, Riemenschneider K, Slesur L, Chen SC, Johnson CA, Yang J, Blevins A, Yan C, Johnson DB, Al-Rohil RN, Halilovic E, Kauffmann RM, Kelley M, Ayers GD, Richmond A
Sci Transl Med. 2019 11 (505)

PMID: 31413145 · PMCID: PMC7584132 · DOI:10.1126/scitranslmed.aav7171

MeSH Terms (21)

Analysis of Variance Animals Blotting, Western Cell Cycle Cell Survival Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase 6 Cyclin-Dependent Kinase Inhibitor p21 Dimethyl Sulfoxide DNA Replication Humans Immunoprecipitation MCF-7 Cells Melanoma Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Proteomics Proto-Oncogene Proteins c-mdm2 Radioimmunoprecipitation Assay

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