Identification of drug-specific public TCR driving severe cutaneous adverse reactions.

Pan RY, Chu MT, Wang CW, Lee YS, Lemonnier F, Michels AW, Schutte R, Ostrov DA, Chen CB, Phillips EJ, Mallal SA, Mockenhaupt M, Bellón T, Tassaneeyakul W, White KD, Roujeau JC, Chung WH, Hung SI
Nat Commun. 2019 10 (1): 3569

PMID: 31395875 · PMCID: PMC6687717 · DOI:10.1038/s41467-019-11396-2

MeSH Terms (18)

Adoptive Transfer Adult Aged Animals Carbamazepine Disease Models, Animal Female HLA-B15 Antigen Humans Male Mice, Transgenic Middle Aged Receptor-CD3 Complex, Antigen, T-Cell Receptors, Antigen, T-Cell, alpha-beta Severity of Illness Index Skin Stevens-Johnson Syndrome T-Lymphocytes, Cytotoxic

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