Further exploration of an N-aryl phenoxyethoxy pyridinone-based series of mGlu NAMs: Challenging SAR, enantiospecific activity and in vivo efficacy.

Yamada Y, Yohn SE, Gilliland K, Loch MT, Schulte ML, Rodriguez AL, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW
Bioorg Med Chem Lett. 2019 29 (18): 2670-2674

PMID: 31358468 · DOI:10.1016/j.bmcl.2019.07.030

MeSH Terms (11)

Animals Anti-Anxiety Agents Antidepressive Agents Dose-Response Relationship, Drug Mice Molecular Structure Pyridones Rats Receptors, Metabotropic Glutamate Stereoisomerism Structure-Activity Relationship

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