Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone.

Reddish MJ, Guengerich FP
J Biol Chem. 2019 294 (35): 12975-12991

PMID: 31296661 · PMCID: PMC6721951 · DOI:10.1074/jbc.RA119.009830

MeSH Terms (8)

18-Hydroxycorticosterone Aldosterone Biocatalysis Cytochrome P-450 CYP11B2 Humans Kinetics Models, Molecular Molecular Conformation

Connections (1)

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