SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M PAMs.

Chopko TC, Han C, Gregro AR, Engers DW, Felts AS, Poslusney MS, Bollinger KA, Morrison RD, Bubser M, Lamsal A, Luscombe VB, Cho HP, Schnetz-Boutaud NC, Rodriguez AL, Chang S, Daniels JS, Stec DF, Niswender CM, Jones CK, Wood MR, Wood MW, Duggan ME, Brandon NJ, Conn PJ, Bridges TM, Lindsley CW, Melancon BJ
Bioorg Med Chem Lett. 2019 29 (16): 2224-2228

PMID: 31248774 · PMCID: PMC6690795 · DOI:10.1016/j.bmcl.2019.06.032

MeSH Terms (8)

Aldehyde Oxidase Animals Drug Discovery Humans Myotonia Congenita Rats Receptor, Muscarinic M4 Structure-Activity Relationship

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