Peripherally delivered hepatopreferential insulin analog insulin-406 mimics the hypoglycaemia-sparing effect of portal vein human insulin infusion in dogs.

Gregory JM, Kraft G, Scott MF, Neal DW, Farmer B, Smith MS, Hastings JR, Madsen P, Kjeldsen TB, Hostrup S, Brand CL, Fledelius C, Nishimura E, Cherrington AD
Diabetes Obes Metab. 2019 21 (10): 2294-2304

PMID: 31183936 · PMCID: PMC8132115 · DOI:10.1111/dom.13808

MeSH Terms (14)

Animals Blood Glucose Diabetes Mellitus, Type 1 Dogs Gluconeogenesis Humans Hypoglycemia Hypoglycemic Agents Infusions, Intravenous Insulin Insulin, Regular, Human Liver Male Portal Vein

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