A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation.

Sammons RM, Perry NA, Li Y, Cho EJ, Piserchio A, Zamora-Olivares DP, Ghose R, Kaoud TS, Debevec G, Bartholomeusz C, Gurevich VV, Iverson TM, Giulianotti M, Houghten RA, Dalby KN
ACS Chem Biol. 2019 14 (6): 1183-1194

PMID: 31058487 · PMCID: PMC7105935 · DOI:10.1021/acschembio.9b00093

MeSH Terms (11)

Binding Sites Crystallography, X-Ray Dose-Response Relationship, Drug Enzyme Activation Guanidine Humans Mitogen-Activated Protein Kinase 1 Nuclear Magnetic Resonance, Biomolecular Phosphorylation Protein Kinase Inhibitors Substrate Specificity

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