Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology.

Möller HE, Bossoni L, Connor JR, Crichton RR, Does MD, Ward RJ, Zecca L, Zucca FA, Ronen I
Trends Neurosci. 2019 42 (6): 384-401

PMID: 31047721 · DOI:10.1016/j.tins.2019.03.009

Although iron is crucial for neuronal functioning, many aspects of cerebral iron biology await clarification. The ability to quantify specific iron forms in the living brain would open new avenues for diagnosis, therapeutic monitoring, and understanding pathogenesis of diseases. A modality that allows assessment of brain tissue composition in vivo, in particular of iron deposits or myelin content on a submillimeter spatial scale, is magnetic resonance imaging (MRI). Multimodal strategies combining MRI with complementary analytical techniques ex vivo have emerged, which may lead to improved specificity. Interdisciplinary collaborations will be key to advance beyond simple correlative analyses in the biological interpretation of MRI data and to gain deeper insights into key factors leading to iron accumulation and/or redistribution associated with neurodegeneration.

Copyright © 2019. Published by Elsevier Ltd.

MeSH Terms (7)

Brain Brain Chemistry Humans Iron Myelin Sheath Neurobiology Neuroimaging

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