Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer's disease.

Roby DA, Ruiz F, Kermath BA, Voorhees JR, Niehoff M, Zhang J, Morley JE, Musiek ES, Farr SA, Burris TP
PLoS One. 2019 14 (4): e0215004

PMID: 30973894 · PMCID: PMC6459530 · DOI:10.1371/journal.pone.0215004

MeSH Terms (13)

Alzheimer Disease Amyloid beta-Peptides Animals Cognitive Dysfunction Disease Models, Animal Disks Large Homolog 4 Protein Hippocampus Male Mice Nuclear Receptor Subfamily 1, Group D, Member 1 Peptide Fragments Pyrrolidines Thiophenes

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