Point mutations in the PDX1 transactivation domain impair human β-cell development and function.

Wang X, Sterr M, Ansarullah , Burtscher I, Böttcher A, Beckenbauer J, Siehler J, Meitinger T, Häring HU, Staiger H, Cernilogar FM, Schotta G, Irmler M, Beckers J, Wright CVE, Bakhti M, Lickert H
Mol Metab. 2019 24: 80-97

PMID: 30930126 · PMCID: PMC6531841 · DOI:10.1016/j.molmet.2019.03.006

MeSH Terms (17)

Adult Carboxylic Ester Hydrolases Cell Differentiation Cell Line Diabetes Mellitus Female Homeodomain Proteins Humans Insulin-Secreting Cells Insulin Secretion Loss of Function Mutation Male Point Mutation Protein Domains RNA, Long Noncoding Trans-Activators Transcription Factors

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