VU0810464, a non-urea G protein-gated inwardly rectifying K (K 3/GIRK) channel activator, exhibits enhanced selectivity for neuronal K 3 channels and reduces stress-induced hyperthermia in mice.

Vo BN, Abney KK, Anderson A, Marron Fernandez de Velasco E, Benneyworth MA, Daniels JS, Morrison RD, Hopkins CR, Weaver CD, Wickman K
Br J Pharmacol. 2019 176 (13): 2238-2249

PMID: 30924523 · PMCID: PMC6555862 · DOI:10.1111/bph.14671

MeSH Terms (14)

Animals Anxiety Behavior, Animal Brain Cells, Cultured Female Fever G Protein-Coupled Inwardly-Rectifying Potassium Channels Male Mice, Inbred C57BL Mice, Transgenic Neurons Sinoatrial Node Stress, Psychological

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