Surveying heterocycles as amide bioisosteres within a series of mGlu NAMs: Discovery of VU6019278.

Reed CW, Washecheck JP, Quitlag MC, Jenkins MT, Rodriguez AL, Engers DW, Blobaum AL, Conn PJ, Niswender CM, Lindsley CW
Bioorg Med Chem Lett. 2019 29 (10): 1211-1214

PMID: 30910459 · DOI:10.1016/j.bmcl.2019.03.016

MeSH Terms (11)

Allosteric Regulation Amides Animals Central Nervous System Hepatocytes Heterocyclic Compounds Inhibitory Concentration 50 Pyrazoles Rats Receptors, Metabotropic Glutamate Structure-Activity Relationship

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