On-target Resistance to the Mutant-Selective EGFR Inhibitor Osimertinib Can Develop in an Allele-Specific Manner Dependent on the Original EGFR-Activating Mutation.

Brown BP, Zhang YK, Westover D, Yan Y, Qiao H, Huang V, Du Z, Smith JA, Ross JS, Miller VA, Ali S, Bazhenova L, Schrock AB, Meiler J, Lovly CM
Clin Cancer Res. 2019 25 (11): 3341-3351

PMID: 30796031 · PMCID: PMC6548651 · DOI:10.1158/1078-0432.CCR-18-3829

MeSH Terms (17)

Acrylamides Alleles Aniline Compounds Carcinoma, Non-Small-Cell Lung Cell Line, Tumor Dose-Response Relationship, Drug Drug Resistance, Neoplasm ErbB Receptors Exons Gene Expression Profiling Humans Lung Neoplasms Models, Molecular Mutation Protein Binding Protein Kinase Inhibitors Structure-Activity Relationship

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