Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical models.

Lu T, Chen C, Wang A, Jiang Z, Qi Z, Hu Z, Hu C, Liu F, Wang W, Wu H, Wang B, Wang L, Qi S, Wu J, Wang W, Tang J, Yan H, Bai M, Liu Q, Liu J
Cancer Lett. 2019 447: 105-114

PMID: 30684595 · DOI:10.1016/j.canlet.2019.01.024

MeSH Terms (11)

Anilides Antineoplastic Agents Cell Line, Tumor Drug Repositioning Drug Resistance, Neoplasm Gastrointestinal Stromal Tumors Humans Imatinib Mesylate Mutation Proto-Oncogene Proteins c-kit Pyridines

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