Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8 T cells.

Gemta LF, Siska PJ, Nelson ME, Gao X, Liu X, Locasale JW, Yagita H, Slingluff CL, Hoehn KL, Rathmell JC, Bullock TNJ
Sci Immunol. 2019 4 (31)

PMID: 30683669 · PMCID: PMC6824424 · DOI:10.1126/sciimmunol.aap9520

MeSH Terms (16)

Animals Antineoplastic Agents, Immunological CD8-Positive T-Lymphocytes Cell Line, Tumor Glucose Glucose Transporter Type 1 Glycolysis Hepatitis A Virus Cellular Receptor 2 Humans Immunoglobulin G Immunotherapy, Adoptive Lymphocytes, Tumor-Infiltrating Melanoma Mice, Inbred C57BL Phosphopyruvate Hydratase Programmed Cell Death 1 Receptor

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