Novel M positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands.

Poslusney MS, Salovich JM, Wood MR, Melancon BJ, Bollinger KA, Luscombe VB, Rodriguez AL, Engers DW, Bridges TM, Niswender CM, Conn PJ, Lindsley CW
Bioorg Med Chem Lett. 2019 29 (3): 362-366

PMID: 30580918 · PMCID: PMC6690489 · DOI:10.1016/j.bmcl.2018.12.039

MeSH Terms (9)

Allosteric Regulation Amides Dose-Response Relationship, Drug Humans Hydrogen Bonding Ligands Molecular Structure Receptor, Muscarinic M4 Structure-Activity Relationship

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