The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu PAM development candidate.

Panarese JD, Engers DW, Wu YJ, Guernon JM, Chun A, Gregro AR, Bender AM, Capstick RA, Wieting JM, Bronson JJ, Macor JE, Westphal R, Soars M, Engers JE, Felts AS, Rodriguez AL, Emmitte KA, Jones CK, Blobaum AL, Conn PJ, Niswender CM, Hopkins CR, Lindsley CW
Bioorg Med Chem Lett. 2019 29 (2): 342-346

PMID: 30503632 · DOI:10.1016/j.bmcl.2018.10.050

MeSH Terms (10)

Allosteric Regulation Dose-Response Relationship, Drug Drug Discovery Heterocyclic Compounds, 2-Ring Humans Isoquinolines Molecular Structure Myotonin-Protein Kinase Receptors, Metabotropic Glutamate Structure-Activity Relationship

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