Dual carrier-cargo hydrophobization and charge ratio optimization improve the systemic circulation and safety of zwitterionic nano-polyplexes.

Jackson MA, Bedingfield SK, Yu F, Stokan ME, Miles RE, Curvino EJ, Hoogenboezem EN, Bonami RH, Patel SS, Kendall PL, Giorgio TD, Duvall CL
Biomaterials. 2019 192: 245-259

PMID: 30458360 · PMCID: PMC6534819 · DOI:10.1016/j.biomaterials.2018.11.010

MeSH Terms (14)

Animals Cations Cell Line, Tumor Female Humans Hydrophobic and Hydrophilic Interactions Mice, Inbred BALB C Mice, Nude Nanostructures Neoplasms Polymers RNA, Small Interfering RNAi Therapeutics Tissue Distribution

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