HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design.

Flyak AI, Ruiz S, Colbert MD, Luong T, Crowe JE, Bailey JR, Bjorkman PJ
Cell Host Microbe. 2018 24 (5): 703-716.e3

PMID: 30439340 · PMCID: PMC6258177 · DOI:10.1016/j.chom.2018.10.009

MeSH Terms (17)

Antibodies, Neutralizing Antibodies, Viral Binding Sites Disulfides Drug Design Epitopes Hepacivirus Hepatitis C Hepatitis C Antibodies Humans Immunoglobulin G Models, Molecular Protein Conformation Sequence Alignment Viral Envelope Proteins Viral Hepatitis Vaccines X-Ray Diffraction

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