Light-activatable cannabinoid prodrug for combined and target-specific photodynamic and cannabinoid therapy.

Ling X, Zhang S, Liu Y, Bai M
J Biomed Opt. 2018 23 (10): 1-9

PMID: 30334393 · DOI:10.1117/1.JBO.23.10.108001

Cannabinoids are emerging as promising antitumor drugs. However, complete tumor eradication solely by cannabinoid therapy remains challenging. In this study, we developed a far-red light activatable cannabinoid prodrug, which allows for tumor-specific and combinatory cannabinoid and photodynamic therapy. This prodrug consists of a phthalocyanine photosensitizer (PS), reactive oxygen species (ROS)-sensitive linker, and cannabinoid. It targets the type-2 cannabinoid receptor (CB2R) overexpressed in various types of cancers. Upon the 690-nm light irradiation, the PS produces cytotoxic ROS, which simultaneously cleaves the ROS-sensitive linker and subsequently releases the cannabinoid drug. We found that this unique multifunctional prodrug design offered dramatically improved therapeutic efficacy, and therefore provided a new strategy for targeted, controlled, and effective antitumor cannabinoid therapy.

(2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).

MeSH Terms (14)

Animals Antineoplastic Agents Cannabinoids Cell Line, Tumor Cell Survival HEK293 Cells Humans Indoles Mice Organosilicon Compounds Photochemotherapy Photosensitizing Agents Prodrugs Reactive Oxygen Species

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