Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA.

Moore E, Grifoni A, Weiskopf D, Schulten V, Arlehamn CSL, Angelo M, Pham J, Leary S, Sidney J, Broide D, Frazier A, Phillips E, Mallal S, Mack SJ, Sette A
Hum Immunol. 2018 79 (12): 821-822

PMID: 30278218 · PMCID: PMC6537871 · DOI:10.1016/j.humimm.2018.09.008

DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 496 healthy adult donors from San Diego, California, to characterize allele frequencies in support of studies of T cell responses to common allergens. Deviations from Hardy Weinberg proportions were detected at each locus except A and C. Several alleles were found in more than 15% of individuals, including the class II alleles DPB1∗02:01, DPB1∗04:01, DQA1∗01:02, DQA1∗05:01, DQB1∗03:01, and the class I allele A∗02:01. Genotype data will be available in the Allele Frequencies Net Database (AFND 3562).

Copyright © 2018. Published by Elsevier Inc.

MeSH Terms (22)

Adolescent Adult Alleles California Female Gene Frequency Genotype Genotyping Techniques Histocompatibility Testing HLA-A Antigens HLA-B Antigens HLA-C Antigens HLA-DP Antigens HLA-DQ Antigens HLA-DR Antigens Humans Linkage Disequilibrium Male Middle Aged Sequence Analysis, DNA T-Lymphocytes Young Adult

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