Photostable, hydrophilic, and near infrared quaterrylene-based dyes for photoacoustic imaging.

Yu J, Pin S, Lin X, Su M, Bai M, Kim K
Mater Sci Eng C Mater Biol Appl. 2018 93: 1012-1019

PMID: 30274031 · PMCID: PMC6172961 · DOI:10.1016/j.msec.2018.09.008

Novel near-infrared contrast agents based on the quaterrylene structure were strategically developed and tested for high photo-stability. Both a dendrimeric quaterrylene molecule, QR-G2-COOH, and a small molecule cationic quaterrylene dye, QR-4PyC4, remain optically stable and continue to generate a competitive photoacoustic response when irradiated by short near-infrared laser pulses for a relatively long time in an in-vitro cell study, unlike indocyanine green that rapidly decreases photoacoustic signal amplitude. The small molecule dye, QR-4PyC4 exhibits not only significantly higher cellular uptake rate than QR-G2-COOH and indocyanine green, but also low toxicity at a concentration of up to 10 μM. The dendrimeric dye, QR-G2-COOH that has surface functional groups available for conjugation with targeting and therapeutic agents shows the highest photoacoustic amplitude with high optical stability. Therefore, QR-4PyC4 can be a promising universal, sensitive and reliable photoacoustic contrast agent and QR-G2-COOH has great potential as a nano-platform with stable photoacoustic imaging capability.

Copyright © 2018 Elsevier B.V. All rights reserved.

MeSH Terms (8)

Cell Line, Tumor Contrast Media Dendrimers Fluorescent Dyes Humans Infrared Rays Optical Imaging Photoacoustic Techniques

Connections (1)

This publication is referenced by other Labnodes entities:

Links