Photostable, hydrophilic, and near infrared quaterrylene-based dyes for photoacoustic imaging.

Yu J, Pin S, Lin X, Su M, Bai M, Kim K
Mater Sci Eng C Mater Biol Appl. 2018 93: 1012-1019

PMID: 30274031 · PMCID: PMC6172961 · DOI:10.1016/j.msec.2018.09.008

Novel near-infrared contrast agents based on the quaterrylene structure were strategically developed and tested for high photo-stability. Both a dendrimeric quaterrylene molecule, QR-G2-COOH, and a small molecule cationic quaterrylene dye, QR-4PyC4, remain optically stable and continue to generate a competitive photoacoustic response when irradiated by short near-infrared laser pulses for a relatively long time in an in-vitro cell study, unlike indocyanine green that rapidly decreases photoacoustic signal amplitude. The small molecule dye, QR-4PyC4 exhibits not only significantly higher cellular uptake rate than QR-G2-COOH and indocyanine green, but also low toxicity at a concentration of up to 10 μM. The dendrimeric dye, QR-G2-COOH that has surface functional groups available for conjugation with targeting and therapeutic agents shows the highest photoacoustic amplitude with high optical stability. Therefore, QR-4PyC4 can be a promising universal, sensitive and reliable photoacoustic contrast agent and QR-G2-COOH has great potential as a nano-platform with stable photoacoustic imaging capability.

Copyright © 2018 Elsevier B.V. All rights reserved.

MeSH Terms (8)

Cell Line, Tumor Contrast Media Dendrimers Fluorescent Dyes Humans Infrared Rays Optical Imaging Photoacoustic Techniques

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