PD-1 up-regulation on CD4 T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production.

Celada LJ, Kropski JA, Herazo-Maya JD, Luo W, Creecy A, Abad AT, Chioma OS, Lee G, Hassell NE, Shaginurova GI, Wang Y, Johnson JE, Kerrigan A, Mason WR, Baughman RP, Ayers GD, Bernard GR, Culver DA, Montgomery CG, Maher TM, Molyneaux PL, Noth I, Mutsaers SE, Prele CM, Peebles RS, Newcomb DC, Kaminski N, Blackwell TS, Van Kaer L, Drake WP
Sci Transl Med. 2018 10 (460)

PMID: 30257954 · PMCID: PMC6263177 · DOI:10.1126/scitranslmed.aar8356

MeSH Terms (24)

Adult Aged Animals Bleomycin CD4-Positive T-Lymphocytes Cell Proliferation Collagen Type I Disease Models, Animal Female Fibroblasts Gene Expression Regulation Humans Idiopathic Pulmonary Fibrosis Interleukin-17 Male Mice Middle Aged Programmed Cell Death 1 Receptor RNA, Messenger Sarcoidosis STAT3 Transcription Factor Th17 Cells Transforming Growth Factor beta1 Up-Regulation

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