Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu).

Bollinger SR, Engers DW, Panarese JD, West M, Engers JL, Loch MT, Rodriguez AL, Blobaum AL, Jones CK, Thompson Gray A, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR
J Med Chem. 2019 62 (1): 342-358

PMID: 30247901 · DOI:10.1021/acs.jmedchem.8b00994

MeSH Terms (15)

Allosteric Regulation Amides Animals Brain Catalepsy Cytochrome P-450 CYP1A2 Half-Life Haloperidol Humans Isoxazoles Male Rats Rats, Sprague-Dawley Receptors, Metabotropic Glutamate Structure-Activity Relationship

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