Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16.

Shi CH, Rubel C, Soss SE, Sanchez-Hodge R, Zhang S, Madrigal SC, Ravi S, McDonough H, Page RC, Chazin WJ, Patterson C, Mao CY, Willis MS, Luo HY, Li YS, Stevens DA, Tang MB, Du P, Wang YH, Hu ZW, Xu YM, Schisler JC
PLoS Genet. 2018 14 (9): e1007664

PMID: 30222779 · PMCID: PMC6160236 · DOI:10.1371/journal.pgen.1007664

MeSH Terms (21)

Animals Behavior, Animal Cognition CRISPR-Cas Systems Disease Models, Animal Female Humans Male Mice Mice, Inbred C57BL Models, Molecular Motor Activity Mutagenesis, Site-Directed Phenotype Point Mutation Protein Domains Protein Multimerization Rats Rats, Sprague-Dawley Spinocerebellar Ataxias Ubiquitin-Protein Ligases

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