Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.

Hunter RW, Hughey CC, Lantier L, Sundelin EI, Peggie M, Zeqiraj E, Sicheri F, Jessen N, Wasserman DH, Sakamoto K
Nat Med. 2018 24 (9): 1395-1406

PMID: 30150719 · PMCID: PMC6207338 · DOI:10.1038/s41591-018-0159-7

MeSH Terms (19)

Adenosine Monophosphate Aminoimidazole Carboxamide Animals Base Sequence Chickens Disease Models, Animal Fructose-Bisphosphatase Glucose Glucose Intolerance Homeostasis Humans Hypoglycemia Liver Metformin Mice, Inbred C57BL Mutation Obesity Prodrugs Ribonucleotides

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