Activation of the mGlu metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M muscarinic receptor allosteric modulators.

Yohn SE, Foster DJ, Covey DP, Moehle MS, Galbraith J, Garcia-Barrantes PM, Cho HP, Bubser M, Blobaum AL, Joffe ME, Cheer JF, Jones CK, Lindsley CW, Conn PJ
Mol Psychiatry. 2020 25 (11): 2786-2799

PMID: 30116027 · PMCID: PMC6588501 · DOI:10.1038/s41380-018-0206-2

MeSH Terms (8)

Allosteric Regulation Animals Antipsychotic Agents Glutamic Acid Mice Mice, Inbred C57BL Receptor, Muscarinic M4 Receptors, Metabotropic Glutamate

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