Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins.

Paxman R, Plate L, Blackwood EA, Glembotski C, Powers ET, Wiseman RL, Kelly JW
Elife. 2018 7

PMID: 30084354 · PMCID: PMC6080950 · DOI:10.7554/eLife.37168

MeSH Terms (11)

Activating Transcription Factor 6 Amides Endoplasmic Reticulum Endoplasmic Reticulum Stress HEK293 Cells Humans Phenylpropionates Prodrugs Signal Transduction Small Molecule Libraries Unfolded Protein Response

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