VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.

Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, Liu XD, Jonasch E, Xie L, Chen X, Yao X, Teh BT, Tan P, Zheng X, Li M, Lawrence C, Fan J, Geng J, Liu X, Hu L, Wang J, Liao C, Hong K, Zurlo G, Parker JS, Auman JT, Perou CM, Rathmell WK, Kim WY, Kirschner MW, Kaelin WG, Baldwin AS, Zhang Q
Science. 2018 361 (6399): 290-295

PMID: 30026228 · PMCID: PMC6154478 · DOI:10.1126/science.aap8411

MeSH Terms (18)

Animals Carcinoma, Renal Cell Chromatin Immunoprecipitation Female Gene Expression Regulation, Neoplastic Homeodomain Proteins Humans Hydroxylation Kidney Neoplasms Mice Mice, SCID Molecular Targeted Therapy Mutation NF-kappa B Oncogenes Substrate Specificity Transcription Factors Von Hippel-Lindau Tumor Suppressor Protein

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