The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production.

Sausville LN, Gangadhariah MH, Chiusa M, Mei S, Wei S, Zent R, Luther JM, Shuey MM, Capdevila JH, Falck JR, Guengerich FP, Williams SM, Pozzi A
Cancer Res. 2018 78 (17): 4865-4877

PMID: 30012669 · PMCID: PMC6125168 · DOI:10.1158/0008-5472.CAN-17-3977

MeSH Terms (14)

Animals Arachidonic Acid Arachidonic Acids Carcinogenesis Carcinoma, Non-Small-Cell Lung Cell Line, Tumor Cytochrome P-450 CYP2C9 Cytochrome P-450 Enzyme System Eicosanoids Endothelial Cells Humans Mice Polymorphism, Single Nucleotide Xenograft Model Antitumor Assays

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