Hemochromatosis (HFE) Gene Variants Are Associated with Increased Mitochondrial DNA Levels During HIV-1 Infection and Antiretroviral Therapy.

Kallianpur AR, Gerschenson M, Hulgan T, Kaur H, Clifford DB, Haas DW, Murdock DG, McArthur JC, Samuels DC, Simpson DM
AIDS Res Hum Retroviruses. 2018 34 (11): 942-949

PMID: 29968489 · PMCID: PMC6421985 · DOI:10.1089/AID.2018.0025

Some HIV-associated complications involve mitochondrial dysfunction and may be less common in individuals with iron-loading HFE (hemochromatosis gene) variants. We evaluated HFE 845A and 187G alleles in relation to mitochondrial DNA (mtDNA) levels in peripheral blood mononuclear cells from 85 individuals with HIV infection on uninterrupted antiretroviral therapy (ART) for 15 or more consecutive weeks. Carriers of HFE gene variants (N = 24) had significantly higher mtDNA levels than noncarriers (N = 61), after adjusting for age, race, sex, and type of ART [adjusted β-coefficient 297, p-value < .001 for at least one HFE variant], but mtDNA declined among all individuals on study during 48 weeks on ART. Increased cellular mtDNA content may represent a compensatory response to mitochondrial stress that is influenced by iron-loading HFE variants.

MeSH Terms (18)

Adult Alleles Anti-HIV Agents Case-Control Studies CD4 Lymphocyte Count DNA, Mitochondrial DNA Copy Number Variations Female Genotype Hemochromatosis Protein HIV-1 HIV Infections Humans Leukocytes, Mononuclear Male Middle Aged Mitochondria RNA, Viral

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