Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis.

Friggeri L, Hargrove TY, Wawrzak Z, Blobaum AL, Rachakonda G, Lindsley CW, Villalta F, Nes WD, Botta M, Guengerich FP, Lepesheva GI
J Med Chem. 2018 61 (13): 5679-5691

PMID: 29894182 · PMCID: PMC6176729 · DOI:10.1021/acs.jmedchem.8b00641

MeSH Terms (12)

14-alpha Demethylase Inhibitors Antifungal Agents Aspergillus fumigatus Candida albicans Catalytic Domain Chemistry Techniques, Synthetic Crystallography, X-Ray Drug Design Imidazoles Ligands Models, Molecular Sterol 14-Demethylase

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