amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics.

Fan PD, Narzisi G, Jayaprakash AD, Venturini E, Robine N, Smibert P, Germer S, Yu HA, Jordan EJ, Paik PK, Janjigian YY, Chaft JE, Wang L, Jungbluth AA, Middha S, Spraggon L, Qiao H, Lovly CM, Kris MG, Riely GJ, Politi K, Varmus H, Ladanyi M
Proc Natl Acad Sci U S A. 2018 115 (26): E6030-E6038

PMID: 29875142 · PMCID: PMC6042104 · DOI:10.1073/pnas.1717782115

MeSH Terms (12)

Cell Line, Tumor DNA Transposable Elements Drug Resistance, Neoplasm Enzyme Inhibitors ErbB Receptors Gene Amplification Gene Expression Regulation, Neoplastic Humans Lung Neoplasms Proto-Oncogene Proteins c-fyn Proto-Oncogene Proteins c-yes Proto-Oncogene Proteins pp60(c-src)

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