Innate Immunity to : Evolving Paradigms in Soft Tissue and Invasive Infections.

Brandt SL, Putnam NE, Cassat JE, Serezani CH
J Immunol. 2018 200 (12): 3871-3880

PMID: 29866769 · PMCID: PMC6028009 · DOI:10.4049/jimmunol.1701574

causes a wide range of diseases that together embody a significant public health burden. Aided by metabolic flexibility and a large virulence repertoire, has the remarkable ability to hematogenously disseminate and infect various tissues, including skin, lung, heart, and bone, among others. The hallmark lesions of invasive staphylococcal infections, abscesses, simultaneously denote the powerful innate immune responses to tissue invasion as well as the ability of staphylococci to persist within these lesions. In this article, we review the innate immune responses to during infection of skin and bone, which serve as paradigms for soft tissue and bone disease, respectively.

Copyright © 2018 by The American Association of Immunologists, Inc.

MeSH Terms (7)

Animals Bone and Bones Humans Immunity, Innate Skin Staphylococcal Infections Staphylococcus aureus

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