Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its α-Helical Conformation, and Inhibits γ-Secretase Nonselectively in Liposomes.

Kamp F, Scheidt HA, Winkler E, Basset G, Heinel H, Hutchison JM, LaPointe LM, Sanders CR, Steiner H, Huster D
ACS Chem Neurosci. 2018 9 (7): 1702-1713

PMID: 29717863 · PMCID: PMC6051911 · DOI:10.1021/acschemneuro.8b00068

MeSH Terms (14)

Amyloid beta-Protein Precursor Amyloid Precursor Protein Secretases Bexarotene Cholesterol HEK293 Cells Humans Liposomes Molecular Structure Neuroprotective Agents Phosphatidylcholines Protein Conformation, alpha-Helical Protein Domains Receptor, Notch1 Static Electricity

Connections (1)

This publication is referenced by other Labnodes entities:

Links