Discovery of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5.

Felts AS, Rodriguez AL, Morrison RD, Blobaum AL, Byers FW, Daniels JS, Niswender CM, Conn PJ, Lindsley CW, Emmitte KA
Bioorg Med Chem Lett. 2018 28 (10): 1679-1685

PMID: 29705142 · PMCID: PMC6142812 · DOI:10.1016/j.bmcl.2018.04.053

MeSH Terms (13)

Allosteric Regulation Animals Dose-Response Relationship, Drug Drug Discovery Humans Male Molecular Structure Pyrimidines Quinolines Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Structure-Activity Relationship

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