A Novel M PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity.

Rook JM, Bertron JL, Cho HP, Garcia-Barrantes PM, Moran SP, Maksymetz JT, Nance KD, Dickerson JW, Remke DH, Chang S, Harp JM, Blobaum AL, Niswender CM, Jones CK, Stauffer SR, Conn PJ, Lindsley CW
ACS Chem Neurosci. 2018 9 (9): 2274-2285

PMID: 29701957 · PMCID: PMC6146057 · DOI:10.1021/acschemneuro.8b00131

MeSH Terms (17)

Allosteric Regulation Animals Antipsychotic Agents CHO Cells Cognition Cognitive Dysfunction Conditioning, Psychological Cricetulus Exploratory Behavior Fear Mice Morpholines Prefrontal Cortex Pyrazoles Rats Risperidone Seizures

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